This DATASET_MMM_README.txt file was generated on 2021-02-12 by Mikhail Kislin


GENERAL INFORMATION

1. Title of Dataset: Deep Behavioral Phenotyping Of Mouse Autism Models using Open-Field Behavior

2. Author Information
	A. Principal Investigator Contact Information
		Name: Ugne Klibaite 
		Institution: Department of Organismic and Evolutionary Biology, Harvard University
		Address: 26 Oxford St, Cambridge, MA 02138
		Email: klibaite@fas.harvard.edu

	B. Associate or Co-investigator Contact Information
		Name: Mikhail Kislin
		Institution: Princeton Neuroscience Institute, Princeton University
		Address: Washington rd, Princeton, NJ 08540
		Email: mkislin@princeton.edu

	C. Principal Investigator Contact Information
		Name: Joshua W. Shaevitz
		Institution: Department of PhysicsLewis-Sigler Institute for Integrative Genomics, Princeton University
		Address: Washington rd, Princeton, NJ 08540
		Email: shaevitz@princeton.edu

	D. Principal Investigator Contact Information
		Name: Samuel S.-H. Wang
		Institution: Princeton Neuroscience Institute, Princeton University
		Address: Washington rd, Princeton, NJ 08540
		Email: sswang@princeton.edu


3. Date of data collection: from 2018-07-01 till 2019-11-29

4. Geographic location of data collection: Princeton, NJ, USA

5. Information about funding sources that supported the collection of the data:  NIH R01NS045193, R01 MH115750, U19 NS104648


SHARING/ACCESS INFORMATION

1. Links to publications that cite or use the data: https://github.com/PrincetonUniversity/MouseMotionMapper 

2. Was data derived from another source? no
	A. If yes, list source(s): 

3. Recommended citation for this dataset: Klibaite, Ugne; Kislin, Mikhail; Verpeut, Jessica L. ; Sun, Xiaoting ; Shaevitz, Joshua W. ; Wang, Samuel S.-H. (2021), “Deep Behavioral Phenotyping Of Mouse Autism Models using Open-Field Behavior", https://doi.org/10.34770/bzkz-j672


DATA & FILE OVERVIEW

1. File List: 

sampleOFTmovieC57bl6.avi
		Example of Open-Field session for male C57BL/6 mouse
allC100_CON.mat
		behavior clusters over time
allC100_8C_CON.mat
		behavior classes over time
jointsCON.mat					
		The primary experimental data consist of body parts dynamics information from 60 male and 20 female C57BL/6, as well as from ASD models:
		14 Cntnap2 WT, 15 Cntnap2 HET, 10 Cntnap2 KO, 17 L7-Tsc1 WT, 17 L7-Tsc1 HET and 9 L7-Tsc1 HOM mutant mice.
centroids_velocities_CON.mat
		The primary experimental data consist of body centroid dynamics information from 60 male and 20 female C57BL/6, as well as from ASD models:
		14 Cntnap2 WT, 15 Cntnap2 HET, 10 Cntnap2 KO, 17 L7-Tsc1 WT, 17 L7-Tsc1 HET and 9 L7-Tsc1 HOM mutant mice.
GROOM_IDX.mat
		metadata for grooming sorting and analysis 
mouseSkeletonSimple_400.mat
		mouse skeleton used with LEAP 
statsBy100.mat
		metadata for stats
info_8con_8b.mat
		metadata to sort unsupervised behavior clusters into semi-supervised behavior classes
vecsVals_subSelect.mat
		contains results of dimensionality reduction of body-part to body-part distances with online-PCA
trainingSet_new10.mat
		file has a subsampled results of wavelets from full dataset and is used for tSNE and high-dimensional clustering with k-Means to learn representation of the mouse behavior space
OFTboxinstrustions.docx
partlistforOFT.xlsx


2. Are there multiple versions of the dataset? no

METHODOLOGICAL INFORMATION

1. Description of methods used for collection/generation of data: 
For recording in darkness we use IR illumination and sound proof arena, see part list and instructions.
The following acquisition program was used to record mouse behavior in Open-Field with ptgrey cameras https://github.com/bccho/acquireWang

2. Methods for processing the data: 
see https://github.com/PrincetonUniversity/MouseMotionMapper 

3. Instrument- or software-specific information needed to interpret the data: 
see https://github.com/PrincetonUniversity/MouseMotionMapper 

4. Environmental/experimental conditions: See Materials and Methods section of the paper

5. Describe any quality-assurance procedures performed on the data: 

6. People involved with sample collection, processing, analysis and/or submission: 
Klibaite, Ugne; Kislin, Mikhail; Verpeut, Jessica L. ; Sun, Xiaoting ;